American Mississippi River Cruises 2025. On an american river cruise, you can glide along the mississippi, explore the pacific northwest, or experience a number of other regions now served by overnight river cruises. Find and plan your next cruise to mississippi river with cabin price comparison, variety of departure ports and.

Here are the best itineraries they offer, and what you’ll see and do along the way. Experience luxury on the mississippi with 2025 and 2026 itinerary.